Why Autoimmune Disease Affects Women Differently

Autoimmune conditions disproportionately affect women

Autoimmune diseases affect women at disproportionately high rates. In fact, nearly 80% of people diagnosed with autoimmune conditions are female. From rheumatoid arthritis and lupus to Hashimoto’s, multiple sclerosis, and inflammatory bowel disease, many women spend years searching for answers—often feeling dismissed, misunderstood, or told their symptoms are “just stress.”

What’s striking is not just how common autoimmune conditions are in women, but how often they overlap with chronic pain, fatigue, brain fog, sleep disruption, and heightened sensitivity to stress. While autoimmune diseases are complex and multifactorial—shaped by genetics, hormones, environment, and immune function—there’s one piece that often gets overlooked: the nervous system.

The Overlooked Role of the Nervous System

How chronic stress keeps the body in survival mode

Our nervous system plays a powerful role in how the immune system behaves. When the body is under chronic stress—whether physical, emotional, hormonal, or psychological—it can become stuck in a state of high alert. Muscles remain tense. Breathing becomes shallow. Inflammation increases. The body shifts into survival mode, prioritizing protection over repair.

For many women with autoimmune conditions, this state isn’t temporary—it’s constant.

Somatic movement offers a gentle way to work with the nervous system rather than against it. Instead of pushing, stretching aggressively, or trying to “fix” the body, somatics focuses on slow, intentional movements that help the brain relearn how to relax muscles and downshift out of stress patterns.

Muscle Tension, Pain, and the Stress Feedback Loop

Why tight muscles can amplify pain and fatigue

Why does this matter? Because muscles and nerves are deeply connected. When muscles are chronically tight, they send ongoing signals of threat to the brain. That feedback loop keeps the nervous system activated, which can amplify pain, fatigue, and inflammatory responses. Somatic practices aim to interrupt that loop.

How Somatic Movement Supports the Nervous System

What somatic movement is (and what it is not)

Through small, slow movements, the brain is invited to notice areas of holding and gradually release them. This process—sometimes called neuromuscular reeducation—helps reset the resting tone of muscles. Over time, many people notice they’re no longer bracing as much, clenching their jaw, holding their breath, or guarding certain parts of their body.

In a body already managing an autoimmune condition, this reduction in background tension can be meaningful. Less muscular effort means less energy expenditure. Improved breathing supports circulation and oxygenation. A calmer nervous system creates an internal environment more conducive to rest and healing.

Why Slowing Down Can Feel Hard — and Why That’s Normal

Releasing tension vs forcing relaxation

It’s also important to name that slow movement can feel surprisingly difficult. In a culture that values productivity and intensity, moving slowly may feel uncomfortable—even frustrating. Movements can feel shaky, jerky, or uncoordinated at first. This isn’t weakness. It’s your nervous system learning something new: how to release instead of protect.

A Complementary Approach — Not a Replacement for Medical Care

Supporting the whole body in autoimmune disease

Somatics is not a replacement for medical care, medication, or other therapies. But it can be a powerful complement—especially for women who feel like their bodies are constantly “on edge.” It offers agency, awareness, and a way to listen to the body without judgment.

Healing Isn’t About Fighting Your Body

Why safety matters for women with autoimmune disease

For women living with autoimmune disease, healing isn’t about forcing the body to cooperate. It’s about creating safety. Sometimes the most supportive thing you can do is slow down, soften, and allow your nervous system to remember that it doesn’t have to fight all the time.

If you’re living with autoimmune disease and feel like your body is always on edge, you don’t have to figure this out alone.

At Breathe., we take a whole-body, nervous-system–informed approach to care. Our work isn’t about pushing harder — it’s about creating safety, awareness, and support so your body can do less fighting and more healing.

Learn how pelvic health physical therapy and somatic movement may support your nervous system.

Breathe. is unique! Integrative physical therapy for women. Private, personalized care that celebrates client victories, big and small. We believe all women deserve to live energetic, vibrant and active lives and it’s our mission to be a partner in achieving that, by specializing in dry needling, DRA, pants peeing, pregnancy/postpartum pain and recovery, pelvic floor dysfunction, headaches, back pain and other orthopedic concerns.

Appointments available in Des Moines and Iowa City / Cedar Rapids / North Liberty area. www.breatheptw.com